The Committee on Immunology - Curriculum
The Committee on Immunology offers a graduate program of
study leading to the Ph.D. in Immunology. The Committee is dedicated to
the open exchange of ideas among scholars of all fields, a commitment
enhanced by an organizational structure that completely integrates the
basic biological sciences with the clinical sciences. This
multidisciplinary and integrated approach corresponds well with the
reality of the new biology, where molecular and structural techniques
are applied widely and with great success to clinical problems.
The Biomedical Sciences Cluster
The Committee on Immunology is integrated within a
cluster of graduate programs with the Committee on Cancer Biology, the
Committee on Microbiology, the Committee on Molecular Metabolism and
Nutrition and the Department of Pathology Molecular Pathogenesis and
Molecular Medicine Program. The five academic units share a joint
Admissions Committee, several common courses, a seminar series and
additional common events for students and faculty within the
cluster. The goal of the cluster system is to encourage
interdisciplinary interactions among both trainees and faculty, and to
allow students flexibility in designing their particular course of
study.
Students have extensive opportunities for interaction
with the three other clusters within the Biological Sciences Division:
the Molecular Biosciences Cluster; the Darwinian Sciences Cluster; and
the Neurobiology Cluster. These clusters offer courses and
sponsor seminars and symposia open to Immunology students.
First Year Student Advisors
Students in the first year of residence will be assigned
a faculty advisor who is a member of the curriculum committee. Students
should meet with the advisor at least once a quarter during the first
year. These meetings are informal and are meant to help
facilitate transition into the graduate program and to make the first
year as productive as possible. Typical issues that might be
discussed are decisions about course work, acclimation to the graduate
program, progress in courses, choice of lab rotations or any other
issue with which the student would like assistance.
Coursework
Each student is required to take nine formal courses for
the completion of the degree requirements, including six quarters of
Experimental Immunology. These nine courses include the
four immunology programmatic core courses, three basic science courses
and the balance in the form of elective courses. Courses should
be chosen with the advice of the faculty advisor.
It is expected that by the end of the first year, at
least eight of the nine courses should be completed. Thus students
should be enrolled in two-three courses per quarter. For those
students who anticipate the course work to occupy the majority of their
time, completing the course work in satisfactory manner may require
delaying research rotations until the summer of the first year.
To remain in good academic standing, students must
maintain a B average in all graded courses, and receive a B or better
in the required Immunology courses. After each quarter, the curriculum
committee will review the transcripts of the students. Any C must
be balanced by an A at the end of the student's second year.
A Typical First Year Schedule
Autumn Quarter
IMMU 31200: Host Pathogen
Interactions – 1.0 credit
IMMU 40200: Experimental Immunology – 0.5 credit
BSDG 30000: All Stars
2 Basic Science Courses - 1.0 credit each
Winter Quarter
IMMU 31500: Advanced
Immunology I – 1.0 credit IMMU 40200: Experimental Immunology – 0.5
credit
IMMU 40200: Experimental Immunology – 0.5 credit
BSDG 30000: All Stars
1 Basic Science Course - 1.0 credit
Research Rotation
Spring Quarter
IMMU 32000: Advanced
Immunology II - 1.0 credit IMMU 35500: Selected Topics in Immunology –
1.0 credit
IMMU 35500: Selected Topics in Immunology - 1.0 credit
IMMU 40200: Experimental Immunology – 0.5 credit
Research Rotation
Summer Quarter
Research Rotation
AAI Advanced Immunology Class
Oral Preliminary Exam
Immunology Programmatic
Courses
IMMU 31200 Host Pathogen Interactions
This course will explore the basic principals of
host defense against pathogens and pathogens’ strategies to overcome
host immune mechanisms. The course will address evolutionary
aspects of innate and adaptive immune responses, while also studying
specific examples of viral and bacterial interactions with their
hosts. The reviews of relevant immunological mechanisms necessary
for appreciation of host/pathogen interactions will be incorporated in
the studies of specific cases. Chervonsky. Autumn
IMMU 31500 Advanced Immunology 1
Lecture/discussion course that explores the genetic
and molecular basis of immune recognition by B and T lymphocytes.
Specific topics to be discussed include the expression of the antigen
specific receptors on B and T lymphocytes, immunogenetics, the
differentiation of lymphocyte subsets, MHC restriction, cellular
interactions and effector mechanism in immune responses, and the role
of accessory molecules in cellular interactions. Consent of
instructor required. Bendelac. Winter
IMMU 32000 Advanced Immunology 2
This class will explore the molecular and
biochemical mechanisms by which lymphocytes are activated in response
to antigen. This will include an in-depth consideration of the signal
transduction pathways utilized by not only the antigen receptors but
also by those receptors which provide co-stimulation, those which
modulate lymphocyte activation and those which mediate lymphocyte
localization. Finally, we will attempt to understand how these complex
signal transduction cascades integrate to drive such processes as
lymphocyte development, tolerance and the immune response. Clark
and Kee. Spring.
IMMU 35500 Selected Topics
This course is an advanced literature analysis/discussion course
intended primarily for graduate students in Immunology. It will
involve an in depth analysis of a particular topic in Immunology, which
will vary from year to year. Emphasis will be placed on
development of critical thought in evaluation of the scientific
literature. Recent courses have included: (1) Antigen
presentation of pathogenic organisms. (2) Clinical issues in
transplantation and autoimmunity. (3) T cell development and
activation. Guevara. Spring.
IMMU 40200 Experimental Immunology
This course centers around the Immunology Journal
Club and the Immunology Seminar Series and has two purposes. The
first is to provide background knowledge for the seminar given each
week by an outside speaker or a member of the Committee on
Immunology. The second is to allow the students an opportunity to
develop skills in analyzing the literature in Immunology with students
at the same stage of training. There are three parts to the
course. First, each week before the journal club and seminar, a
paper provided by the speakers will be discussed and analyzed by the
students. Second, students will attend the weekly Immunology
seminars. Students will also meet to discuss the papers in detail
in an attempt to understand the aims and methodologies. Students
will attend and participate in the weekly COI Journal Club. First
and second year students are required to participate in this course.
Boone, Gounari, Huang. Autumn, Winter and Spring.
Laboratory Rotations
Graduate students are required to rotate through at
least tw laboratories. Often students will have rotated through
more laboratories before beginning the thesis work. Students may
petition the Committee for a waiver of one rotation. Lab
rotations should be completed by the beginning of the second year.
Preliminary Exams
All first year students are required to take an oral
preliminary exam in the late summer of their first year. The
primary purpose of the exam is to test the student's ability to
synthesize knowledge and concepts in immunology as well as related
areas of basic science. The exam also serves to identify
weaknesses that can be corrected in the students' knowledge or
understanding, and in rare instances, to identify students who may not
be suited for basic research as a career. All first year
immunology students are sent to the American Association of
Immunologists (AAI) Advanced Course in Immunology which takes place
at the University of Minnesota, Minneapolis, MN as preparation for the
prelim.
In the process of preparing for the exam students will
be given a list of topics, and those that have not been formally
covered in course work should be independently studied by the students.
It is hoped that students will work with each other and enhance their
own and their classmates understanding and conceptual grasp of
important issues.
The students are examined by an ad hoc committee which
includes members of the curriculum committee. Grading is on a scale of
1 - 4: (1)=high pass, (2)=pass, (3)=conditional pass, (4)=fail
If a student obtains a conditional pass or fails the
exam, he/she will be allowed to retake some portion of/or the entire
exam within 3 months.
Thesis Research
After successfully completing most of the coursework,
each student should convene a thesis committee, which would advise the
student throughout the research phase of the program. The thesis
committee should be chosen by consultation with the student's
mentor. The committee should have at least five faculty members,
including the mentor. Of those, at least three should be members
of the Committee on Immunology, and it is strongly advised that one of
the members also be a member of the curriculum committee.
Within one year of entry into the thesis laboratory full
time (typically in the summer or fall preceding the third year in the
program), a thesis proposal should be presented to the thesis committee
and defended orally. The written portion should describe the
theoretical framework of the project, relevant preliminary data that
the student has accumulated. The experimental plan should outline
a sequence of experiments to be performed, the potential outcomes of
these experiments and the interpretation and plans based on the outcome
of key experiments.
After approval of the thesis proposal, students are
required to meet with their thesis committee at least once a
year. Meetings are meant to facilitate and monitor progress in
the project and thus can be scheduled more frequently, if faculty input
is sought on particular problems or choices in research direction.
Faculty contact:
Dr. Albert Bendelac
(773) 834-8646
abendela@bsd.uchicago.edu
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