Habibul Ahsan, M.D., MMedSc.
Research Summary
Dr.
Ahsan’s research interests focus on the interplay between environmental
and
genetic factors in cancer and exploiting this information in cancer
prevention
in humans. He published extensively on
the molecular epidemiology of carcinogenic effects of arsenic exposure
and also
on the molecular and genetic epidemiology of hormonal etiology of
breast cancer. His ongoing NIH-funded
major research projects
include: 1) a genome-wide association study to identify novel genes for
early-onset breast cancer among 6,000 breast cancer cases and
population/sister
controls; 2) a prospective cohort study of 15,000 men and women in
Bangladesh
to investigate the intermediate- and long-term carcinogenic effects of
environmental arsenic exposure from drinking water; 3) genetic
susceptibility to arsenic-induced pre-malignant skin lesions and
skin cancers among 3,000 cases and controls; and 4) a randomized
clinical trial
of vitamin E and selenium among 6,000 individuals with pre-malignant
skin
lesions for the prevention of cancers and deaths.
Selected Papers
Journal Articles
Ahsan H, Neugut AI, Bruce JN (1995).
Association of malignant brain tumors and cancers of other sites.
Journal
of Clinical Oncology, 13(12): 2931-2935.
Ahsan H, Neugut AI, Garbowski GC,
Jacobson JS, Forde KA, Treat MR, Waye JD (1998). Family history of
colorectal
adenomatous polyps and increased risk for colorectal cancer. Annals of Internal Medicine, 128(11): 900-905.
Ahsan H, Wang L-Y, Chen
C-J, Tsai W-Y, Santella RM (2001). Variability
in aflatoxin-albumin adduct
levels and effects of hepatitis B and C virus infection and glutathione
S-transferase
M1 and T1 genotype. Environmental
Health Perspectives, 109(8): 833-837.
Ahsan H, Hodge SE, Heiman GA, Begg
MD, Susser ES (2002). Relative risk for genetic associations: the
case-parent triad as
a variant of case-cohort design. International Journal of Epidemiology,
31: 669-678.
Ahsan H (2003). Placental genes and breast cancer:
Can the
offspring’s or father’s genotypes be predictive of mother’s risk? Epidemiology, 14(2):
251-3.
Ahsan H, Rundle AG (2003). Measures of genotype
versus gene
products: promise and pitfalls in cancer prevention.
Carcinogenesis, 24(9): 1429-1434.
Ahsan
H and Thomas DC (2004). Lung Cancer Etiology:
Independent and Joint Effects of Genetics, Tobacco, and Arsenic. JAMA,
292(24): 3026-3029.
Ahsan H, Whittemore AS, Chen
Y, Senie RT, Hamilton SP, Wang Q, Gurvich I, Santella RM (2005). Variants in estrogen-biosynthesis genes CYP17
and
CYP19
and breast cancer risk: A family-based genetic association study. Breast
Cancer Research, 7(1): R71-R81.
Greenlee
H, Chen
Y, Kabat GC, Wang Q, Kibriya
M, Gurvich I, Sepkovic DW,
Bradlow HL,
Senie RT,
Santella RM, Ahsan H
(2006). Variants in estrogen
biosynthesis and metabolism genes and urinary estrogen metabolites in
women
with a family history of breast cancer. Breast
Cancer Research & Treatment 2006 (July 19), Published Online.
Argos M, Kibriya MG, Jasmine
F, Parvez
MF, Ahsan H (2006). Differential gene
expression patterns in peripheral mononuclear cells by arsenic exposure
from
drinking water and arsenic-related skin lesions in Bangladesh
population. Cancer
Epidemiology Biomarkers Prevention, 15(7): 1367-1375.
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