Department of Surgery
Section of Transplantation Surgery
Committee on Immunology
Committee on Molecular Metabolism
Ph.D. Australian National University, 1985
B.Sc. University of Malaya, 1981
Phone: (773) 702-5521
The University of Chicago
SBRI J547 MC 5026
5841 South Maryland Avenue
Chicago, Illinois 60637
Related Research Interests:
Anita S. Chong, Ph.D.
Transplantation Tolerance, Mechanisms of Rejection, and
the Regulation of T and B Cell Responses to Allografts
central theme of my research is to understand how the immune system
discriminates between self-and non-self and how immune events
subsequent to this discrimination event are regulated. The primary
focus of my research on basic and translational issues of transplant
tolerance. The possibility that tolerance to a transplanted organ can
be induced is tremendously attractive, as it would obviate the need for
expensive and dangerous chronic immunosuppression. However, it has
become clear that, despite the numerous successes in inducing tolerance
in rodent transplant models, transplant tolerance in humans remains an
elusive goal. My laboratory has developed a tolerance-induction
strategy in mice, involving the transplantation of intact bone
fragments as a stable source of donor cells along with transient
therapy with anti-CD40 monoclonal antibodies. We are actively
investigating the mechanism for allograft tolerance, focusing on
peripheral regulatory events.
A second area of investigation
for my laboratory stems from the realization that the supply of human
organs cannot adequately satisfy the needs of humans requiring
transplantation. Thus, for transplantation to realize its potential in
the treatment of human disease, alternative sources of organs must be
developed. I thus decided to devote some of my research efforts to
understanding the immunology of antibody-mediated xenograft rejection
We believe that these studies, which will
elucidate what properties of antibodies determine whether they are
pathogenic, non-pathogenic or even protective, will have application to
xenotransplantation and also provide insights into the roles of
antibodies in allotransplantation.
third area of investigation in my laboratory focuses on issues related
to the application of islet transplantation as a cure for Type I
diabetes. We have developed a project that aims at defining and
preventing the early inflammatory events that result early islet
destruction following intraportal injection. More recently, we have
embarked on studies investigation alternative sources of islet stem
Ogawa H, Mohiuddin MM, Yin DP, Shen J, Chong AS, and
Galili U. 2004. Mouse-heart grafts expressing an incompatible
carbohydrate antigen. II. Transition from accommodation to tolerance.
Yin, D-P, Zeng, H, Ma, L, Shen, J, Byrne, GW, and Chong, AS.
2004. Cutting Edge: Natural killer (NK) cells mediate
IgG1-dependent hyperacute rejection of xenografts. J Immunol: 172:7235.
Hara, M, Yin, D, Dizon, RF, Han, M, Shen, J, Chong, AS, and Bindokas,
VP. 2004. A mouse model for studying intrahepatic islet
transplantation. Transplantation 78:615.
Li, D, Gal, I, Vermes, C, Alegre, M-L, Chong, ASF, Chen, L., Shao, Q,
Vyasheslava, A, Xu, X, Koreny, T, Mikecz, K, Finnegan, A, Glant, TT,
and Zhang, J. 2004. Cutting Edge: Cbl-b: A key
molecule involved in CD28- and CTLA-4 mediated T cell
costimulation. J. Immunol. 173:7135.
Yu P, Lee Y, Liu W, Krausz T, Chong A, Schreiber, H and Fu, YX.
2005. Intra-tumor depletion of CD4+ cells unmasks tumor
immunogenicity leading to rejection of established tumor. J Exp Med
Yin, D, Ding, D, Shen, J, Ma, L, Hara, M, and Chong, AS.
2006. Liver ischemia contributes to early islet failure following
intraportal transplantation: Benefits of liver
ischemic-preconditioning. Am J. Transpl. 6: 60.
Chong, AS, Zeng, H, Knight DA, Shen J., Meister GT, Williams, JW, and
Waldman J. 2006. Concurrent Anti-viral and Immunosuppressive
Activities of Leflunomide in vivo. Am J. Transpl. 6: 69.
Chong, AS, Shen, J, Tao, J, Yin, D, Kunetzov, A, Hara, M, and
Philipson, LH. 2006. Reversing diabetes in NOD mice without
spleen cell-derived beta-cell regeneration. Science 311:1774-5.
^Chen, L, ^Wang, T, Zhou, P, Ma, L, Yin, D, Shen, J, Molinero, L,
Nozaki, T, Phillips, T, Wang, C-R, Fairchild, RL, *Alegre, M-L, and
*Chong, AS. 2006. TLR Engagement Prevents Transplantation
Tolerance. Am. J. Transpl. 6: 2282. ^Co-first author; *Co-last
Yin, D, Tao, J, Lee, DD, Shen, J, Hara, M, Lopez, J, Kunetzov, A, and
Philipson, LH, and Chong, AS. 2006. Recovery of islet
beta-cell function in streptozotocin-induced diabetic mice: An
indirect role for the spleen. Diabetes 55:3256-63.
Chong, AS, Shen, J, Tao, J, Yin, D, Kunetzov, A, Hara, M, and
Philipson, LH. 2006. Response to Comment on Chong et al. on
Diabetes reversal in NOD mice. Science 314:1243.
Kirk, AD, Baldwin, WM, Cascalho, MI, Chong, AS, Sykes, M, West,
LJ. 2007. American Society of Transplantation symposium on B
cells in transplantation: harnessing humoral immunity from rodent
models to clinical practice. Am. J. Transplant. 7:1464.
Li, Y, Ma, L, Yin, D, Shen, J and Chong, AS. 2007. Peripheral
Deletion of Allo-reactive B Cells Induced by Costimulation
Blockade. Proc. Nat. Acad. Sc. 104:12093.
Ding, JW, Zhou, TT, Zeng, HZ, Ma, L, Verbeek2, JS, Yin, D, Shen, J, and
Chong, AS. 2008. Hyperacute rejection by anti-Gal IgG1, IgG2a and
IgG2b is dependent on complement and Fc-gamma receptors. J.
Ding, JW, Zhou, TT, Ma, L, Yin, D, Shen, J, Ding, CYP, Tang, IY, Byrne,
GW and Chong, AS. 2008. Expression of complement regulatory
proteins in accommodated xenografts induced by anti-α-Gal IgG1 in a
rat-to-mouse model. Am. J. Transplant. 8:32-40
Ma L, Xiang Z, Sherrill TP, Wang L, Blackwell TS, Williams P, Chong A,
Chari R, Yin DP. 2008. Bioluminescence imaging visualizes
activation of nuclear factor-kappaB in mouse cardiac
transplantation. Transplantation 85:903-910.
Alegre ML, Leemans J, Le Moine A, Florquin S, De Wilde V, Chong A,
Goldman M. 2008. The Multiple Facets of Toll-Like Receptors in
Transplantation Biology. Transplantation 86:1-9.
Xiang Z, Ma LL, Manicassamy S, Ganesh BB, Williams P, Chari R, Chong A,
Yin DP. 2008. CD4+ T cells are sufficient to elicit allograft
rejection and major histocompatibility complex class I molecule is
required to induce recurrent autoimmune diabetes after pancreas
transplantation in mice. Transplantation 85:1205-11.
Li Y, Ma L, Yin D, Shen J, Chong AS. 2008. Long-term control of
alloreactive B cell responses by the suppression of T cell help.
Wang T, Chen L, Ahmed E, Ma L, Yin D, Zhou P, Shen J, Xu H, Wang CR,
Alegre ML, Chong AS. 2008. Prevention of allograft tolerance by
bacterial infection with Listeria monocytogenes. J
Lee DD, Grossman E, Chong AS. 2008. Cellular therapies for type 1
diabetes. Horm Metab Res. 40:147-54. Review.
Faculty and Research