|
Appointments:
Assistant Professor
Department of Surgery
Committee on Molecular Medicine/MPMM
|
Education:
Ph.D., Northwestern
University 2003
M.S., University of Texas at
Austin 1998
B.S., Rice
University 1995
|
Contact:
Phone: (773) 834-4161
Fax: (773)
834-4546
E-Mail:
jcollier@surgery.bsd.uchicago.edu
Lab
Information
Address:
The University of Chicago
Abbott 522, (MC 5032)
5841 South Maryland Avenue
Chicago, Illinois 60637
|
Related Research Interests:
|
|
Joel Collier, Ph.D.
Molecular Biomaterials for Tissue Repair
Research Summary
Research
in our laboratory focuses on designing novel synthetic biomaterials and
investigating how they may be engineered to direct biological
processes. We are particularly interested in understanding how
assemblies of proteins, peptides, polymers, and conjugates of these
molecules can be constructed into synthetic extracellular matrices
capable of directing cell behavior in vitro (e.g. as defined 3-D
culture media) or in vivo (e.g. as scaffolds for Regenerative
Medicine). Our research questions center around three interconnected
areas:
1) Investigating structure-function relationships that determine how
molecular design impacts folding and assembly into nanostructures
(fibrils, networks, and gels), and how the physical, chemical,
mechanical, and biological properties of the assembled material may be
subtly modulated through choices in molecular design.
2) Understanding how cells interact with defined synthetic
extracellular matrices so that the matrices can be systematically tuned
to favor particular cell phenotypes.
3) Understanding how molecular design and assembly state directs
tissue-level or organism-level responses. We are primarily interested
in understanding how assemblies of peptides and proteins engage
inflammatory and immune responses so that they can be engineered to
modulate these processes locally. Although these questions and
approaches are applicable to many tissues, we are currently focusing on
epithelial and endothelial tissues, as these tissues mediate the
interfaces of physiology.
Selected Papers
J.P. Jung, A.K. Nagaraj, E.K. Fox, J.S. Rudra, J.M. Devgun, and J.H.
Collier, ³Co-assembling peptides as defined matrices for endothelial cells,² Biomaterials 30(12) 2400-2410 (2009).
W.L. Murphy and J.H. Collier, ³Self-Assembling Biomaterials,² Acta Biomaterialia, 5(3) 803-804 (2009).
P. Jing, J.P. Jung, and J.H. Collier, ³Nanostructured Materials Constructed from Polypeptides,² in NanoScience in Biomedicine, D. Shi, Editor, Springer, New York (2009).
Li HC, Collier JH, Shawki A, Rudra JS, Li EY, Mackenzie B, Soleimani M,
³Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure,² J Membr Biol. (2009) Mar;228(2):111-24.
P. Jing, J. S. Rudra, A. B. Herr, and J. H. Collier ³Self-assembling peptide polymers designed from the coiled coil region of fibrin² Biomacromolecules
9(9): 2438-46 (2008).
J.H. Collier, ³Modular self-assembling biomaterials for directing cellular responses,² Soft Matter 4 (12) 2310-2315 (2008).
J.P. Jung, S. A. Cronier, J. L. Jones, and J.H. Collier ³Modulating the mechanical properties of self-assembled peptide culture matrices via native chemical ligation,² Biomaterials, 29, 2143-2151 (2008).
J.A. Kopechek, T. M. Abruzzo, B. Wang, S.M. Chrzanowski D.A.B. Smith, P.
Kee, S.L. Huang, J.H. Collier, D.D. McPherson, C.K. Holland, ³Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes,² Journal of Ultrasound in Medicine 27(11) 1597-1606 (2008).
J. H. Collier and M. Mrksich, ³Engineering a Biospecific Communication Pathway Between Cells and Electrodes,² Proceedings of the National Academy of Sciences, USA, 103 (7), 2021-2025 (2006).
J. H. Collier and P. B. Messersmith, ³Nanostructural Tailoring of Self-Assembled Peptide Structures,² Advanced Materials, 16 (11), 907-910 (2004).
J. H. Collier and P. B. Messersmith, ³Enzymatic Modification of Self-Assembling Peptide Structures with Tissue Transglutaminase,² Bioconjugate Chemistry, 14 (4), 748-755 (2003).
C.H. Thomas, J.H. Collier, C.S. Sfeir, and K.E. Healy, ³Engineering Gene Expression and Protein Synthesis by Modulation of Nuclear Shape,² Proceedings of the National Academy of Sciences, USA, 99(4), 1972-1977 (2002).
J.H. Collier, B.H. Hu, J.W. Ruberti, J. Zhang, P. Shum, D. H. Thompson, and P.B. Messersmith, ³Thermally and Photochemically Triggered Self-Assembly of Peptide Hydrogels,² Journal of the American Chemical Society, 123, 9463-9464 (2001).
J.H. Collier, J.P. Camp, T.W. Hudson, C.E. Schmidt, ³Synthesis and Characterization of Polypyrrole/ Hyaluronic Acid composites for peripheral nerve regeneration,² Journal of Biomedical Materials Research 50(4), 574-84 (2000).
|
