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Appointments:
Assistant Professor
Department of Surgery
Committee on Molecular Metabolism and
Nutrition
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Education:
M.D., Northwestern University
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Contact:
Phone: (773) 702-5305
Fax: (773)
702-4442
E-Mail:
mgrassi@bsd.uchicago.edu
Address:
The University of Chicago
AMB S201J, (MC 2114)
5841 South Maryland Avenue
Chicago, Illinois 60637
Lab
Website
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Related Research Interests:
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Michael A. Grassi, M.D.
Clinical
Discovery: Translational Approaches to
Retinal Disease
Research Summary
Translational research, which is a marriage between basic science and
clinical investigation, is being carried out in our program with the
goal of making significant contributions to the development of novel
molecularly targeted treatments for retinal disease. The aim of our
research program is to use genomics in a multi-faceted and
interdisciplinary, systems-oriented approach to understand the
molecular basis of common blinding retinal conditions, such as diabetic
retinopathy, age-related macular degeneration and retinitis pigmentosa.
Vision loss is the most feared disability, and the anticipated numbers
of affected individuals with retinal disease over the coming years is
staggering. Numerous ophthalmologic conditions have been
identified and exquisitely described, however, the basic underlying
pathogenic mechanisms remain to be determined. Using cell lines,
patient samples, and donor eyes we are conducting genome-wide
association studies; cellular screening experiments with small
molecules; genome-wide RNA interference; and DNA expression analyses in
order to identify the molecular mechanisms that contribute to retinal
disease.
Selected Papers
Grassi
MA: The gift. J Am Med Association. (1996), 276(11):854.
Tamarina NA, Grassi MA, Johnson DA, Pearce WH: Proteoglycan gene
expression is decreased in abdominal aortic aneurysms. Journal of
Surgical Research. (1998), 74:76-80.
Grassi MA, Lee AG: Lymphomatous meningitis of the Burkitt type
presenting with multiple cranial neuropathies. American Journal
of Ophthalmology. (2002), 133:424-425.
Grassi MA, Petersen DB, Kirby P, Weingeist TA, Wagoner MD: Severe
ocular injury resulting from a rooster attack. Saudi Journal of
Ophthalmology. (2003), 17:176-178.
Grassi MA, Lee AG, Kardon RH, Nerad JA: A lot of clot.
Survey of Ophthalmology. Clinical Challenges. (2003),
48(5):555-561.
Grassi MA, Alward WLM, Verdick RL, Langlow EP, Kwon YH: Atypical
pigment dispersion syndrome in a child. American Journal of
Ophthalmology. (2004), 137(4):753-6.
Sokal I, Dupps WJ, Grassi MA, Brown J Jr, Affatigato LM, Roychowdhury
N, Yang L, Filipek S, Palczewski K, Stone EM, Baehr W: A novel
GCAP1 Missense mutation (L151F) in a large family with autosomal
dominant cone-rod dystrophy (adCORD). Investigative Ophthalmology
& Visual Sciences. (2005) 46(4):1124-32.
Mullins RF, Grassi MA, Skeie JM. Glycoconjugates of choroidal
neovascular membranes in age-related macular degeneration.
Molecular Vision. (2005). 14;11:509-17.
Grassi MA, Fingert JH, Scheetz TE, Roos BR, Ritch R, West SK, Kawase K,
Shire AM, Mullins RF, Stone EM. Ethnic variation in AMD-associated
complement factor H polymorphism p.Tyr402His. Human
Mutation. (2006), 27(9):921-5.
Grassi MA, Folk JC, Scheetz TE, Taylor CM, Sheffield VC, Stone EM.
Complement factor H Polymorphism p.Tyr402His and cuticular
drusen. Archives of Ophthalmology. (2007), 125(1)93-97.
Thomas G*, Grassi MA*, Lee JR, Edwards AO, Gorin MB, Klein R, Casavant
TL, Scheetz TE, Stone EM, Williams AB. IDOCS: intelligent
distributed ontology consensus system - the use of machine learning in
retinal drusen phenotyping. Investigative Ophthalmology &
Visual Science. (2007), 48(5)2278-84. (*joint first author).
Fingert JH, Grassi, MA, Janutka JC, East JS, Howard JG, Sheffield, VC
Jacobson, DM Hayreh, SS Stone, EM. Mitochondrial variant G4132A is
associated with familial non-arteritic anterior ischemic optic
neuropathy in one large pedigree. Ophthalmic Genetics. (2007),
28(1)1-7.
Hariprasad SM, Miller L, Mieler W, Grassi MA, Green JL, Jager RD.
Vision-related quality of life in patients with diabetic macular edema.
British Journal of Ophthalmology. (2007 June 21).
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