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Vinay Kumar, M.B.B.S., M.D., FRCPathCellular and molecular biology of murine natural killer (NK) cellsResearch SummaryOur laboratory is interested in the cellular and molecular biology of murine natural killer (NK) cells. These cells are believed to act as the first line of defense against tumors and viral infections. In addition they secrete a variety of cytokines including 1FN-g and GM-CSF that can influence the inflammatory response. Two aspects of NK cell biology are of particular interest to us: the development of NK cells from multipotent progenitor cells, and the identification of NK cell receptors and their ligands.
Selected PapersWilliams NS, Kubota A, Bennett M, Kumar V, and Takei F. (2000) Clonal analysis of NK cell development from bone marrow progenitors in vitro: orderly acquisition of receptor gene expression. Eur J Immunol., 30(7): 2074-82.Stepp SE, Mathew PA, Bennett M, de Saint Basile G, Kumar V. (2000) Perforin: more than just an effector molecule. Immunology Today 21(6): 254-6. Liu J, Morris MA, Nguyen P, George TC, Lai WC, Schatzle JD, Kumar V, Bennett M. (2000) Ly49I natural killer cell receptor transgene inhibition of H2b mouse bone marrow transplant rejection. J Immunol.164:1793-9. Boles KS, Stepp SE, Bennett M, Kumar V, Mathew PA. (2001) 2B4 (CD244) and CS1: Novel members of the CD2 subset of the Ig superfamily molecules expressed on JK cells and other leukocytes. Immunol Rev. 181:234-49. Catalina F, Speciale SG, Kumar V, Milewich L, Bennett M. (2001). Food Restriction-like effects on dietary dehydroepiandrosterone. Hypothalamic neurotransmitters and metabolites in male C57BL/6 and (C57BL/6 x DBA/2)F1 mice. Experimental Biology Medicine 226:208-15. Taylor MA, Chaudhary PM, Klem J, Kumar V, Schatzle JD, Bennett M. (2001) Inhibition of the death receptor pathway by cFLIP confers partial engraftment of MHC class I-deficient stem cells and reduces tumor clearance in perforin-deficient mice. J Immunol Oct 15; 167(8):4230-7. Morris MA, Liu J, Arora V, George TC, Klem J, Schatzle JD, Kumar V, Bennett M. (2002) B6 Strain Ly49I Inhibitory Gene Expression on T Cells in FVB.Ly49I(B6) Transgenic Mice Fails to Prevent Normal T Cell Functions. J Immunol. (2002) Oct 1; 169(7):3661-6. Klem J, Verrett PC, Kumar V, Schatzle JD. (2002). 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function. J Immunol Jul 1; 169(1):55-62. Lian RH, Kumar V. (2002) Murine natural killer cell progenitors and their requirements for development. Semin Immunol Dec; 14(6):453-60. Morris MA, Koulich E, Liu J, Arora V, George TC, Schatzle JD, Kumar V, Bennett M. (2002) Definition of additional functional ligands for Ly49I(B6) using FVBLy49I(B6) transgenic mice and B6 natural killer cell effectors. Transplantation Nov 27; 74(10):1449-54. Kouro T, Kumar V, Kincade PW. (2002) Relationships between early B- and NK-lineage lymphocyte precursors in bone marrow. Blood Nov 15; 100(10):3672-80. Lee KM, Bhawan S, Majima T, Wei H, Nishimura MI, Yagita H, Kumar V. (2003) Cutting Edge: The NK Cell Receptor 2B4 Augments Antigen-Specific T Cell Cytotoxicity Through CD48 Ligation on Neighboring T Cells. J Immunol. May 15;170(10):4881-5 Kawamura T, Koka R, Ma A, Kumar V. (2003) Differential Roles for IL-15R α-Chain in NK Cell Development and Ly-49 Induction. J. Immunol. 2003 Nov 15;171(10):5085-90. Catalina F, Milewich L, Kumar V, Bennett M. (2003) Dietary dehydroepiandrosterone inhibits bone marrow and leukemia cell transplants: role of food restriction. Exp Biol Med (Maywood). 2003 Dec; 228(11): 1303-20. Kumar V, Abbas AK, and Fausto N. (2004) Pathologic Basis of Disease, 7th edition, W.B. Saunders Co., Philadelphia, PA Lee KM, McNerney ME, Stepp SE, Mathew PA, Schatzle JD, Bennett M, Kumar V. (2004) 2B4 Acts As a Non-Major Histocompatibility Complex Binding Inhibitory Receptor on Mouse Natural Killer Cells. J. Exp. Med. May 3; 199(9):1245-54. [See also commentary, page 1175 same issue]. Lian RH, Chin RK, Nemeth HE, Libby SL, Fu YX, Kumar V. (2004) A role for lymphotoxin in the acquisition of Ly49 receptors during NK cell development. Eur J Immunol. Oct;34(10):2699. Kumar V, McNerney M. (2005) A New Self: MHC-Class-I-Independent Natural-Killer-Cell Self-Tolerance. Nature Reviews Immunology. May; 5:363-74. McNerney ME., Guzior, D, Kumar V. (2005) 2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice. Blood. Aug; 106:1337-40. Lee KM, Forman JP, McNerney ME, Stepp S, Kuppireddi S, Guzior D, Latchman YE, Sayegh M H, Yagita H, Park CK, Oh S B, Wulfing C, Schatzle J, Mathew PA, Sharpe AH, Kumar V. (2005) Requirement of homotypic NK cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functions. Blood. May; doi:10.1182/blood-2005-01-0185. McNerney ME, Lee KM, Zhou P, Molinero L, Mashayekhi M, Guzior D, Sattar H, Kuppireddi S, Wang CR, Kumar V, Alegre ML. (2006) Role of natural killer cell subsets in cardiac allograft rejection. Am J Transplant. Mar;6(3):505-13. McNerney ME, Kumar V. (2006) The CD2 family of natural killer cell receptors. Curr Top Microbiol Immunol.;298:91-120. Taniguchi RT, Guzior D, Kumar V. (2007) 2B4 inhibits NK cell fratricide. Blood First Edition Paper, prepublished online May 30, 2007 DOI 10.1182/blood-2007-02-076927. Alejandro C, Deng L, Chlewicki LK, Fernández MM, Kumar V, Mariuzza RA. (2007) Structure of Natural Killer Receptor 2B4 Bound to CD48 Reveals Basis for Heterophilic Recognition in Signaling Lympocyte Activation Molecule Family. Immunity. October; 27: 572-84. Kumar V, Abbas AK, Fausto N, and Mitchell RM (2007) Basic Pathology, 8th edition, W.B. Saunders, Philadelphia, PA Chlewicki LK, Velikovsky AC, Balakrishman V, Mariuzza RA, Kumar V. (2008) Molecular Basis of the Dual Functions of 2B4 (CD244). J. Immunol.; 180: 8159-67 PMID: 18523281 |
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