Vinay Kumar, M.B.B.S., M.D., FRCPath
Cellular and molecular biology of murine natural killer
Our laboratory is interested in the cellular and
molecular biology of murine natural killer (NK) cells. These cells are
believed to act as the first line of defense against tumors and viral
infections. In addition they secrete a variety of cytokines including
1FN-g and GM-CSF that can influence the inflammatory response. Two
aspects of NK cell biology are of particular interest to us: the
development of NK cells from multipotent progenitor cells, and the
identification of NK cell receptors and their ligands.
Lian R and Kumar V. Use of stem cell radiation chimeras to analyze how domains of specific proteins impact on murine NK cell development in vivo. Methods Mol Biol. 2010; 612:51-65. PMID: 20033634 [PubMed - indexed for MEDLINE]
Chlewicki LK and Kumar V. A model system for studying NK cell receptor signaling. Methods Mol Biol. 2010;612:177-98; PMID: 20033641 [PubMed - indexed for MEDLINE]
Kim EO, Kim N, Kim K, Kim TW, Kumar V, Lee KM. Unidirectional signaling triggered through 2B4 (CD244), not CD48, in murine NK cells. J Leukoc Biol. 2010 Oct:88(4):707-14. PMID: 20647560 [PubMed – indexed for MEDLINE]
Kim EO, Kim TJ, Kim N, Kim ST, Kumar V, Kee KM. Homotypic cell to cell cross-talk among human natural killer cells reveals differential and overlapping roles of 2B4 and CD2. J Biol Chem. 2010 Dec 31;285(53):41755-64.
PMID: 20813844 [PubMed – in process] PMCID: PMC3009903 [Available on 2011/12/31]