Arthur and Marian Edelstein Professor
Department of Medicine
Department Human Genetics
Director, The University of Chicago Comprehensive Cancer Center (UCCCC)
Director, Cancer Cytogenetics Laboratory
The Ben May Department for Cancer Research
Committee on Cancer Biology
Committee on Genetics
Ph.D., University of Illinois-Chicago, 1981
M.S., University of Illinois-Chicago, 1978
B.S., Purdue University, 1976
Phone: (773) 702-0795
The University of Chicago
AMB H212Q, (MC 1140)
5841 South Maryland Avenue
Chicago, Illinois 60637
Website (Cancer Research Center)
Website (Ben May)
Related Research Interests:
Michelle Le Beau, Ph.D.
Molecular Analysis of Recurring Chromosomal
Abnormalities in Human Tumors; Identification of Cooperating Mutations
and Genetic Pathways Leading to Transformation
Human tumors are characterized by recurring chromosomal
abnormalities. During the past decade, the genes that are located at
the breakpoints of a number of recurring chromosomal abnormalities in
human tumors have been identified. Molecular analysis has revealed,
that alterations in the level of expression of these genes, or in the
properties of the encoded proteins resulting from the chromosomal
rearrangement, play an integral role in the process of malignant
transformation. Dr. Le Beau has had a long-standing interest in
identifying the recurring chromosomal abnormalities in human tumors,
and correlating specific chromosomal abnormalities with morphological
and clinical features of the neoplastic disease, such as response to
therapy and survival.
Ongoing projects include:
1) Molecular cloning of a myeloid leukemia-related gene
involved in the 5/del(5q) characteristic of the major subtype of
therapy-related acute myeloid leukemia (alkylating-agent induced).
2) Genetic characterization of murine models for acute
myeloid leukemia (RUNX1/ETO, PML-RARA, BXH2, NF1+/-, K-RAS), and
identification of secondary, cooperating mutations and genetic pathways
to leukemogenesis. Application of murine models for pre-clinical drug
3) Elucidation of the mechanism for the genetic
instability characteristic of chromosomal fragile sites (loci which are
prone to undergo breakage and rearrangement). These studies involve the
analysis of DNA replication and cell cycle checkpoints in fragile site
instability, as well as the role of DNA repair pathways in mediating
repair of damage at fragile sites.
Lucas I, Palakodeti A, Jiang Y, Young DJ, Jiang N, Fernald AA, Le Beau MM. High throughput mapping of origins of replication in human cells. EMBO Rep 8:770-777, 2007.
Joslin JM, Fernald AA, Tennant TR, Davis EM, Kogan SC, Anastasi J, Crispino JD, Le Beau MM. Haploinsufficiency of EGR1, a candidate gene in the del(5q), leads to the development of myeloid disorders. Blood 110:719-726, 2007.
Qian Z, Chen L, Fernald AA, Williams BO, Le Beau MM. A critical role for Apc in hematopoietic stem and progenitor cell survival. J Exp Med 205:2163-75, 2008.
Shannon KM, Le Beau MM. Cancer: hay in a haystack. Nature 451:252-253, 2008.
Jiang Y, Lucas I, Young DJ, Davis EM, Karrison T, Rest JS, Le Beau MM. Common fragile sites are characterized by histone hypoacetylation. Hum Mol Genet 18:4501-4512, 2009.
Wang J, Fernald AA, Anastasi J, Le Beau MM, Qian Z. Haploinsufficiency of Apc leads to ineffective hematopoiesis. Blood 115:3481-3488, 2010.
Palakodeti A, Lucas I, Jiang Y, Young DJ, Fernald AA, Karrison T, Le Beau MM. Impaired replication dynamics at the FRA3B common fragile site. Hum Mol Genet 19:99-110, 2010.
Stoddart A, Tennant TR, Fernald AA, Anastasi J, Brodsky FM, Le Beau MM. The clathrin-binding domain of CALM-AF10 alters the phenotype of myeloid neoplasms in mice. Oncogene. 2011 Jun 27. doi: 10.1038/onc.2011.251.
Odenike O, Le Beau MM. The dawn of the molecular era of the myelodysplastic syndromes. N Engl J Med 364:2545-6, 2011.
Faculty and Research