Dorothy Sipkins, M.D., Ph.D.

Molecular Characteristics of Tissue Microenvironments Fostering the Survival and Regeneration of Both Normal and Cancerous Hematopoietic Stem Cells; the Impact of Malignant Growth on the Function of the Normal Hematopoietic Stem Cell Niche.

Research Summary

Selected Papers

Storrs RW, Tropper FD, Li HY, Song, CK, Kuniyoshi JK, Sipkins DA, Li KCP, Bednarski MD. Paramagnetic Polymerized Liposomes: Synthesis, Characterization, and Applications for Magnetic Resonance Imaging. Journal of the American Chemical Society 117:7301-7306; 1995

Sipkins DA, Cheresh DA, Kazemi M, Nevin LM, Bednarski MD, Li KCP. Detection of Tumor Angiogenesis In Vivo by alphavbeta3-targeted Magnetic Resonance Imaging. Nature Medicine 4(5):623-626; 1998

Sipkins DA, Tropper FD, Gijbels K, Steinman L, Bednarski MD, Li KCP. ICAM-1 Expression in Autoimmune Encephalitis Visualized Using Magnetic Resonance Imaging. Journal of Neuroimmunology 104(1):1-9; 2000

Wei X, Sipkins DA, Pitsillides CM, Novak J, Georgakoudi I, Lin CP. Real-Time Detection of Circulating Apoptotic Cells by In Vivo Flow Cytometry. Molecular Imaging 4(4):415-416; 2005

Sipkins DA, Wei X, Wu JW, Runnels J, Cote D, Means T, Luster AD, Scadden DT, Lin CP. In Vivo Imaging of Specialized Bone Marrow Endothelial Microdomains for Tumor Engraftment. Nature 435(7044):969-973; 2005

A. Colmone, M. Amorim, A.L. Pontier, S. Wang, E. Jablonski, D.A. Sipkins.  Leukemic Cells Create Bone Marrow Niches that Disrupt the Behavior of Normal Hematopoietic Progenitor Cells.  Science 322(5909):1861-5; 2008