Appointments:

Assistant Professor
Department of Medicine
Section of Hematology/Oncology

Committee on Cancer Biology
Committee on Immunology
Committee on Molecular Medicine/MPMM

Education:

M.D., Ph.D. Standford University
        School of Medicine, 1999

    B.S. Stanford University, 1990

Contact:

Phone: (773) 834-8634

Fax: (773) 702-3163

E-Mail: dsipkins@medicine.bsd.uchicago.edu

Address:

The University of Chicago
AMB P312, (MC 2115)
5841 South Maryland Avenue
Chicago, Illinois 60637

Lab: AMB N618

Lab Website

Related Research Interests:

Dorothy Sipkins, M.D., Ph.D.

Molecular Characteristics of Tissue Microenvironments Fostering the Survival and Regeneration of Both Normal and Cancerous Hematopoietic Stem Cells; the Impact of Malignant Growth on the Function of the Normal Hematopoietic Stem Cell Nich.

Research Summary

Dr. Sipkins' research focuses on defining the molecular characteristics of tissue microenvironments, or "niches", that foster the survival and regeneration of both normal and cancerous hematopoietic stem cells. Her laboratory also examines the impact of malignant growth on the function of the normal hematopoietic stem cell niche. In combination with classical molecular and cell biology approaches, her lab will utilize state-of-the-art multiphoton and confocal optical imaging techniques to explore these questions in vivo, in real-time.

Selected Papers

Storrs RW, Tropper FD, Li HY, Song, CK, Kuniyoshi JK, Sipkins DA, Li KCP, Bednarski MD. (1995). Paramagnetic Polymerized Liposomes: Synthesis, Characterization, and Applications for Magnetic Resonance Imaging. Journal of the American Chemical Society 117:7301-7306.

Sipkins DA, Cheresh DA, Kazemi M, Nevin LM, Bednarski MD, Li KCP. (1998). Detection of Tumor Angiogenesis In Vivo by alphavbeta3-targeted Magnetic Resonance Imaging. Nature Medicine 4(5):623-626.

Sipkins DA, Tropper FD, Gijbels K, Steinman L, Bednarski MD, Li KCP. (2000). ICAM-1 Expression in Autoimmune Encephalitis Visualized Using Magnetic Resonance Imaging. Journal of Neuroimmunology 104(1):1-9.

Wei X, Sipkins DA, Pitsillides CM, Novak J, Georgakoudi I, Lin CP. (2005). Real-Time Detection of Circulating Apoptotic Cells by In Vivo Flow Cytometry. Molecular Imaging 4(4):415-416.

Sipkins DA, Wei X, Wu JW, Runnels J, Cote D, Means T, Luster AD, Scadden DT, Lin CP. (2005). In Vivo Imaging of Specialized Bone Marrow Endothelial Microdomains for Tumor Engraftment. Nature 435(7044):969-973.

Faculty and Research

Programs

Cancer Biology

Immunology

Microbiology

Molecular Metabolism
and Nutrition

Molecular Pathogenesis and
Molecular Medicine