Kenneth Thompson, Ph.D.

Research Summary

The long-term objectives of my research are to discover new antiviral agents in plants and to explore their value in the treatment and prevention of infections by several viruses that have a significant impact on the public health. This research focuses on the identification, purification, and characterization of antiviral compounds present in plants and on the investigation of their effectiveness against herpes simplex virus (HSV), human cytomegalovirus (HCMV), varicella zoster virus (VZV), and human immunodeficiency virus (HIV).

Selected Papers

Arnow PM, Zachary KC, Thistlethwaite JR, Thompson KD, Bova JL and Newell KA. (1998). Pathogenesis of early operative site infections after orthotopic liver transplantation. Transplantation 65:1500-03.

Thompson K. (1998). Antiviral activity of Viracea® against acyclovir susceptible and acyclovir resistant strains of herpes simplex virus. Antiviral Research 39:55-61.

Neumann MA and Thompson KD. (1998). Acute bacterial meningitis: Prevention and treatment. Clin. Microbiol. Newsletter 20:181-84.

Baunoch DA, Lobell A, Kane D, Fredericks J, Thompson K. (1999). The Development of An Automated In Situ Assay for the Detection of Human Cytomegalovirus in Peripheral Blood Leukocytes. J. Virological Methods 81:31-37.

Oram RJ, Marcellino D, Strauss D, Gustafson E, Talarico CL, Root AK, Sharma PL, Thompson K, Fingeroth JD, Crumpaker C, Herold BC. (2000). Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate. J. Inf. Dis. 181:1458-61.

Oram, R.J., Marcellino, D., Strauss, D., Gustafson, E., Talarico, C.L., Root, A.K., Sharma, P.L., Thompson, K., Fingeroth, J.D., Crumpaker, C., Herold, B.C. (2000). Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate. J. Inf. Dis. 181:1458-61.

Klemens JJ, Thompson K, Langerman A, Naclerio RM. (2006). Persistent inflammation and hyperresponsiveness following viral rhinosinusitis. Laryngoscope. 116(7):1236-40.

Luxameechanporn T, Blair C, Kirtsreesakul V, Thompson K, Naclerio RM. (2006). The effect of treatment with moxifloxacin or azithromycin on acute bacterial rhinosinusitis in mice. Int J Infect Dis. 10(5):401-6.