Committee on Cancer Biology- News


Winter 2008

Genetic variant associated with prostate cancer in African-American men


Two tiny genetic variations may provide the best clues yet for finding more precise ways to estimate prostate cancer risk and improve screening and early detection for men of African descent, report researchers from the University and the Translational Genomics Research Institute in Phoenix, Ariz., in the December issue of Genome Research, published early online.
“This finding emphasizes the importance of ancestry in studying genetics,” said study author Rick Kittles, Associate Professor in Medicine. “Previous studies led us to one specific region of chromosome 8,” he said. “Then this approach—which took advantage of genetic differences among African-American men who are at very high risk for this type of cancer—led us to a different locus within that region and directly to a gene of interest.” (Chronicle, December 2007)

Immune system focus of Huggins series

Learn about cancer and immune system interactions as well as cancer therapies from a University Medical Center expert in a series of eight free lectures beginning Saturday, Jan. 12.
During the sixth annual Charles B. Huggins Lecture Series, cancer and immunology specialist Judy Cannon, a postdoctoral fellow in Medicine, Section of Pulmonary and Critical Care, will talk about how knowing the immune system can help doctors and patients better understand and treat cancer. (Chronicle, January 2008)

Scientists merge mammalian cells from two species, creating chimera


Featured on the cover of the Jan. 1 issue of the journal Human Molecular Genetics, scientists, including Bruce Lahn, a Howard Hughes Medical Institute Investigator and Professor in Human Genetics, as well as others from the the University of Chicago, Sun Yat-sen University, China, and the University of Liverpool, UK, describe how they produced a viable "chimera" - a single organism with two distinct populations of cells from two different sources.
Although both are rodents, the wood mouse (Apodemus sylvaticus) and the house mouse (Mus musculus) have evolved separately for up to 20 million years. Their genes differ by as much as 18 percent, about 12 times the difference between humans and chimpanzee. This is the first time that stem cells from one mammalian species have been shown to contribute extensively to development when introduced into the embryo of another, very different species. (Chronicle, January 2008)

Autumn 2007

Bernard Liu selected as recipient  of 2007-2008 Abbott Graduate Fellowship

The fellowship includes a 10 to 12 week internship at Abbott Laboratories. Liu also won the Committee on Cancer Biology Ehrman Award which recognizes senior students working in the field of cancer biology. His advisor is Dr. Piers Nash.

Joint program with Janelia Farm Research Campus promotes interdisciplinarity


The University of Chicago and the Howard Hughes Medical Institute (HHMI) have launched a new Interdisciplinary Scientist Training Program (ISTP) to train graduate students at Chicago and HHMI's new Janelia Farm Research Campus (JFRC) in Loudoun County, Virginia. The goal of the program is to combine the exceptional academic resources of the University and the highly interdisciplinary research environment of Janelia Farm to train "well-prepared, highly committed, and gifted studets" in the biomedical sciences. The University is one of two partner institutions for the new program, the other being Cambridge University, and the first student began his study in the fall. "Graduate study in biology needs to change," said Dr. Harinder Singh, HHMI investigator and Louis Block Professor in the Department of Molecular Genetics and Cell Biology, who is directing the Chicago program. "We need to give students interdisciplinary training and take advantage of multiple mentors." (The Imprint, Fall 2007)

Summer 2007

Circuit training: Biologist Harinder Singh investigates how cells find their purpose in life.


Harinder Singh, Chicago's Louis Block professor of molecular genetics and cell biology, has developed an approach that models the cell-fate mechanism as a circuit, much as an engineer design an electrical circuit. But where an electrical circuit might map how a light is turned on or off, Singh's circuit maps how genetic triggers turn on gene sets that determine whether a cell becomes a macrophage or neutrophil. Described in an August 2006 Cell, Singh's first cell-fate circuit holds broad promise, he says, that could help create entirely new cell types for therapeutic purposes.
The circuit--a mathematical model of the cell-fate mechanism--was developed using data from an elaborate experimental system. "In biology, generally speaking, people are experimentalists," says Singh, also a Howard Hughes Medical Institute investigator. "We need to better integrate theoretical analysis with the traditional experimental analysis we've been doing in the past." (The University of Chicago Magazine, July-August 2007).



 

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