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Committee on Cancer Biology- News
Winter 2008
Genetic
variant associated with prostate cancer in African-American men

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Two tiny genetic variations may provide the best
clues yet for finding
more precise ways to estimate prostate cancer risk and improve
screening and early detection for men of African descent, report
researchers from the University and the Translational Genomics Research
Institute in Phoenix, Ariz., in the December issue of Genome
Research, published early online.
“This finding emphasizes the importance of ancestry in studying
genetics,” said study author Rick Kittles, Associate Professor in
Medicine. “Previous studies led us to one specific region of chromosome
8,” he said. “Then this approach—which took advantage of genetic
differences among African-American men who are at very high risk for
this type of cancer—led us to a different locus within that region and
directly to a gene of interest.” (Chronicle,
December 2007)
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Immune
system focus of Huggins series
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Learn about cancer and immune system interactions
as well as cancer therapies from a University Medical Center expert in
a series of eight free lectures beginning Saturday, Jan. 12.
During the sixth annual Charles B. Huggins Lecture Series, cancer and
immunology specialist Judy Cannon, a postdoctoral fellow in Medicine,
Section of Pulmonary and Critical Care, will talk about how knowing the
immune system can help doctors and patients better understand and treat
cancer.
(Chronicle,
January 2008)
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Scientists merge mammalian cells from two
species, creating chimera

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Featured on the cover of the Jan. 1 issue of the
journal Human Molecular Genetics,
scientists, including Bruce Lahn, a Howard Hughes Medical Institute
Investigator and Professor in Human Genetics, as well as others from
the the University of Chicago, Sun Yat-sen University, China, and the
University of Liverpool, UK, describe how they produced a viable
"chimera" - a single organism with two distinct populations of cells
from two different sources.
Although both are rodents, the wood mouse (Apodemus sylvaticus) and the house
mouse (Mus musculus)
have evolved separately for up to 20 million years. Their genes differ
by as much as 18 percent, about 12 times the difference between humans
and chimpanzee. This is the first time that stem cells from one
mammalian species have been shown to contribute extensively to
development when introduced into the embryo of another, very different
species. (Chronicle,
January 2008)
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Autumn 2007
Bernard Liu selected as recipient of
2007-2008 Abbott Graduate Fellowship
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The fellowship includes a 10 to 12 week internship
at Abbott Laboratories. Liu also won the Committee on Cancer Biology
Ehrman Award which recognizes senior students working in the field of
cancer biology. His advisor is Dr. Piers Nash.
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Joint program with Janelia Farm Research
Campus promotes interdisciplinarity

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The University of Chicago and the Howard Hughes
Medical Institute (HHMI) have launched a new Interdisciplinary
Scientist Training Program (ISTP) to train graduate students at Chicago
and HHMI's new Janelia Farm Research Campus (JFRC) in Loudoun County,
Virginia. The goal of the program is to combine the exceptional
academic resources of the University and the highly interdisciplinary
research environment of Janelia Farm to train "well-prepared, highly
committed, and gifted studets" in the biomedical sciences. The
University is one of two partner institutions for the new program, the
other being Cambridge University, and the first student began his study
in the fall. "Graduate study in biology needs to change," said Dr.
Harinder Singh, HHMI investigator and Louis Block Professor in the
Department of Molecular Genetics and Cell Biology, who is directing the
Chicago program. "We need to give students interdisciplinary training
and take advantage of multiple mentors." (The Imprint, Fall 2007)
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Summer 2007
Circuit training: Biologist Harinder Singh
investigates how cells find their purpose in life.

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Harinder Singh, Chicago's Louis Block professor of
molecular genetics and cell biology, has developed an approach that
models the cell-fate mechanism as a circuit, much as an engineer design
an electrical circuit. But where an electrical circuit might map how a
light is turned on or off, Singh's circuit maps how genetic triggers
turn on gene sets that determine whether a cell becomes a macrophage or
neutrophil. Described in an August 2006 Cell, Singh's first cell-fate
circuit holds broad promise, he says, that could help create entirely
new cell types for therapeutic purposes.
The circuit--a mathematical model of the cell-fate mechanism--was
developed using data from an elaborate experimental system. "In
biology, generally speaking, people are experimentalists," says Singh,
also a Howard Hughes Medical Institute investigator. "We need to better
integrate theoretical analysis with the traditional experimental
analysis we've been doing in the past." (The
University of Chicago Magazine, July-August 2007).
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Committee On Cancer Biology
News Archive
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